Won Eun Jeong, Shin Jong Hee, Kim Soo Hyun, Choi Min Ji, Byun Seung A, Kim Mi-Na, Lee Wee-Gyo, Lee Kyungwon, Uh Young, Shin Myung Geun, Suh Soon Pal
Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.
Med Mycol. 2018 Jun 1;56(4):501-505. doi: 10.1093/mmy/myx067.
We investigated the in vitro antifungal susceptibilities of cryptic Aspergillus species from nine Korean hospitals. Based on the CLSI epidemiological cutoff values, resistance rates to amphotericin B, itraconazole, voriconazole, posaconazole and caspofungin were as follows: A. awamori (34 isolates; all 0%), A. tubingensis (22; 0%, 4.5%, 0%, 0%, and 0%, respectively), A. sydowii (16; 0%, 6.3%, 0%, 0%, and 6.3%), A. lentulus (2; 50%, 0%, 100%, 50%, and 0%), and A. tamarii (2; all 0%). A. calidoustus (one isolate) showed resistance to multiple drugs. Thus, cryptic species identification can be mandatory for clinically important Aspergillus isolates, with their susceptibility data.
我们调查了来自韩国九家医院的隐匿型曲霉菌种的体外抗真菌药敏情况。根据美国临床和实验室标准协会（CLSI）的流行病学临界值，两性霉素B、伊曲康唑、伏立康唑、泊沙康唑和卡泊芬净的耐药率如下：泡盛曲霉（34株；均为0%）、土曲霉（22株；分别为0%、4.5%、0%、0%和0%）、烟曲霉（16株；0%、6.3%、0%、0%和6.3%）、勒图曲霉（2株；50%、0%、100%、50%和0%）以及塔宾曲霉（2株；均为0%）。热栖曲霉（1株）对多种药物耐药。因此，对于具有临床重要性的曲霉菌分离株及其药敏数据，隐匿型菌种鉴定可能是必不可少的。
