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The global problem of antifungal resistance: prevalence, mechanisms, and management.全球抗真菌耐药性问题：流行率、机制和管理。
Lancet Infect Dis. 2017 Dec;17(12):e383-e392. doi: 10.1016/S1473-3099(17)30316-X. Epub 2017 Jul 31.
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Identification by Molecular Methods and Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry and Antifungal Susceptibility Profiles of Clinically Significant Rare Aspergillus Species in a Referral Chest Hospital in Delhi, India.印度德里一家转诊胸科医院中通过分子方法和基质辅助激光解吸电离飞行时间质谱法鉴定及临床重要罕见曲霉属菌种的抗真菌药敏谱
J Clin Microbiol. 2016 Sep;54(9):2354-64. doi: 10.1128/JCM.00962-16. Epub 2016 Jul 13.
8
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Clin Microbiol Infect. 2016 Aug;22(8):662-9. doi: 10.1016/j.cmi.2016.05.013. Epub 2016 Jun 2.
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Treatment of infections by cryptic Aspergillus species.隐匿性曲霉菌感染的治疗。
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隐匿性曲霉病：一种罕见病症及诊断难题。

Cryptic aspergillosis: a rare entity and a diagnostic challenge.

作者信息

R Lavanya, Ninan Marilyn M, Kurien Regi, N A Fouzia, Sahni Rani D, Michael Joy S

机构信息

Department of Clinical Microbiology, Christian Medical College, Vellore 632004, India.

Department of ENT 3 and Anterior Skull Base Surgery, Christian Medical College, Vellore 632004, India.

出版信息

Access Microbiol. 2022 Apr 12;4(4):000344. doi: 10.1099/acmi.0.000344. eCollection 2022.

DOI:10.1099/acmi.0.000344
PMID:35812705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9260091/
Abstract

INTRODUCTION

Cryptic aspergillosis, caused by cryptic species of , is increasingly reported in humans and causes significant morbidity and mortality in immunocompromised individuals. The main aim of this study was to describe the occurrence of this entity at a large tertiary care centre and analyse the challenges in identifying them in a routine diagnostic laboratory.

METHODS

This was a retrospective case review of all patients diagnosed with cryptic species from April 2019 to February 2020. The isolates were identified using conventional microbiological techniques, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI- TOF MS), 28S rRNA and internal transcribed spacer (ITS) sequencing.

RESULTS

The species identified were and . Identification by MALDI- TOF MS and sequencing was concordant for all except , with MALDI- TOF MS misidentifying it as . All isolates showed low minimum inhibitory concentrations (MICs) for the panel of antifungal drugs.

CONCLUSION

Aspergillosis caused by cryptic species presents a diagnostic challenge. This study confirms the importance of molecular methods for accurate identification.

摘要

引言

由曲霉属隐匿种引起的隐匿性曲霉病在人类中报告日益增多，并在免疫功能低下个体中导致显著的发病率和死亡率。本研究的主要目的是描述该病原体在一家大型三级医疗中心的发生情况，并分析在常规诊断实验室中识别它们所面临的挑战。

方法

这是一项对2019年4月至2020年2月期间所有诊断为曲霉属隐匿种的患者进行的回顾性病例分析。分离株采用传统微生物学技术、基质辅助激光解吸/电离飞行时间质谱（MALDI-TOF MS）、28S rRNA和内转录间隔区（ITS）测序进行鉴定。

结果

鉴定出的菌种为[具体菌种1]和[具体菌种2]。除[具体菌种]外，MALDI-TOF MS和测序的鉴定结果一致，MALDI-TOF MS将其错误鉴定为[错误鉴定的菌种]。所有分离株对抗真菌药物组均显示出低最低抑菌浓度（MIC）。

结论

由曲霉属隐匿种引起的曲霉病存在诊断挑战。本研究证实了分子方法对于准确鉴定的重要性。