Department of Plant Science and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 151-921, Korea.
School of Applied Biosciences, Kyungpook National University, Daegu 702-701, Korea.
J Exp Bot. 2017 Oct 13;68(17):4737-4748. doi: 10.1093/jxb/erx312.
Photoreceptors perceive different wavelengths of light and transduce light signals downstream via a range of proteins. COP1, an E3 ubiquitin ligase, regulates light signaling by mediating the ubiquitination and subsequent proteasomal degradation of photoreceptors such as phytochromes and cryptochromes, as well as various development-related proteins including other light-responsive proteins. COP1 is itself regulated by direct interactions with several signaling molecules that modulate its activity. The control of photomorphogenesis by COP1 is also regulated by its localization to the cytoplasm in response to light. COP1 thus acts as a tightly regulated switch that determines whether development is skotomorphogenic or photomorphogenic. In this review, we discuss the effects of COP1 on the abundance and activity of various development-related proteins, including photoreceptors, and summarize the regulatory mechanisms that influence COP1 activity and stability in plants.
光感受器感知不同波长的光，并通过一系列蛋白质将光信号向下游转导。COP1 是一种 E3 泛素连接酶，通过介导光受体（如光敏色素和隐花色素）以及各种发育相关蛋白（包括其他光响应蛋白）的泛素化和随后的蛋白酶体降解，来调节光信号。COP1 自身的活性受到与其直接相互作用的几种信号分子的调节。COP1 对光形态建成的控制还受到其在细胞质中的定位的调节，以响应光。因此，COP1 作为一个紧密调节的开关，决定了发育是暗形态建成还是光形态建成。在这篇综述中，我们讨论了 COP1 对各种发育相关蛋白（包括光感受器）丰度和活性的影响，并总结了影响植物中 COP1 活性和稳定性的调节机制。
