Denk Nora, Senn Claudia, Jacobsen Bjoern, Schnitzer Tobias
Pharma Research and Early Development (pRED), Pharmaceutical Sciences (PS), Roche Innovation Center Basel, Switzerland.
Lab Anim. 2018 Feb;52(1):93-97. doi: 10.1177/0023677217735550. Epub 2017 Oct 9.
Preputial dilation is an infrequently reported condition in pigs. The pathophysiology and etiology is unclear. Causes for diverticulum dilation are proposed to be chronic preputial diverticulitis with subsequent fibrosis of the preputial cavity, phimosis of the preputial orifice or the preputial diverticulum, but the large majority of cases are reportedly idiopathic in nature. Surgical interventions include ablative procedures, but many cases are not treated because of an assumed lack of clinical relevance in pigs not used for breeding. We report a case of progressive preputial dilation that recurred after surgical intervention. Histopathological examination revealed no primary inflammatory condition, contrary to literature suggesting a role for inflammatory mediators in pathogenesis. Phimosis of the preputial orifice was noted post mortem and might be a contributing factor. These findings partially contradict the current assumptions in regards to pathophysiology and treatment choices in the literature and warrant further investigation into alternative therapeutic interventions for this condition.
包皮扩张在猪中是一种报道较少的病症。其病理生理学和病因尚不清楚。有人提出憩室扩张的原因是慢性包皮憩室炎以及随后包皮腔的纤维化、包皮口或包皮憩室的包茎，但据报道，绝大多数病例本质上是特发性的。手术干预包括切除手术，但由于认为对未用于繁殖的猪缺乏临床相关性，许多病例未得到治疗。我们报告一例手术干预后复发的进行性包皮扩张病例。组织病理学检查未发现原发性炎症，这与文献中认为炎症介质在发病机制中起作用的观点相反。尸检时发现包皮口包茎，这可能是一个促成因素。这些发现部分与文献中关于病理生理学和治疗选择的当前假设相矛盾，因此有必要对这种病症的替代治疗干预措施进行进一步研究。
