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饮水给药氟雷拉纳溶液治疗欧洲商业家禽群体中鸡螨(Dermanyssus gallinae)感染的田间疗效和安全性。

Field efficacy and safety of fluralaner solution for administration in drinking water for the treatment of poultry red mite (Dermanyssus gallinae) infestations in commercial flocks in Europe.

机构信息

MSD Animal Health Innovation GmbH, Zur Propstei 55270, Schwabenheim, Germany.

MSD Animal Health Innovation SAS, 7 rue Olivier de Serres, CS 67131, 49071, Angers Technopole, Beaucouzé, France.

出版信息

Parasit Vectors. 2017 Oct 9;10(1):457. doi: 10.1186/s13071-017-2390-3.

Abstract

BACKGROUND

Welfare concerns, production losses caused by Dermanyssus gallinae, the poultry red mite (PRM), and widespread mite resistance to environmentally applied acaricides continue to drive an urgent need for new and effective control measures. Fluralaner is a novel systemic acaricide developed to address that need. A series of field studies was initiated to investigate the safety and efficacy of a fluralaner solution (10 mg/ml) administered in drinking water at a dose rate of 0.5 mg/kg on two occasions with a 7-day interval, for treatment of natural PRM infestations in chickens.

METHODS

Blinded, negative-controlled studies were completed in Europe across eight layer, two breeder, and two replacement chicken farms. At each farm, two similar flocks were housed in similar PRM-infested units (either rooms within a building, or separate buildings) varying from 550 to 100,000 birds per unit. One unit at each farm was allocated to fluralaner treatment, administered in drinking water on Days 0 and 7. One unit remained untreated. Mite traps were placed throughout each unit on Days -1, 0 or 1, 3, 6, 9, and 13 or 14, then at weekly or two-weekly intervals, retrieved after 24 h and processed for mite counts. Efficacy at each farm was assessed by mean PRM count reductions from traps in treated units compared with those from control units. Production parameters and safety were also monitored.

RESULTS

Efficacy was 95.3 to 99.8% on Day 3 and 97.8 to 100% on Day 9, thereafter remaining above 90% for 56 to 238 days after treatment initiation. Post-treatment improvement in egg-laying rate was greater by 0.9 to 12.6% in the treated group at 9 of the 10 layer or breeder farms. There were no treatment-related adverse events.

CONCLUSION

Fluralaner administered at 0.5 mg/kg via drinking water twice, 7 days apart, was well tolerated and highly efficacious against the PRM in naturally infested chickens representing a range of production types and management systems. The results indicate that this novel treatment has potential to be the cornerstone of an integrated approach to reducing or eliminating the welfare and productivity costs of this increasingly threatening pest.

摘要

背景

鸡螨(PRM)引起的福利问题、生产损失以及螨类对环境应用杀螨剂的广泛抗性,继续推动着对新的和有效的控制措施的迫切需求。氟虫腈是一种新型的系统杀螨剂,旨在满足这一需求。开展了一系列田间研究,以调查在两次 7 天间隔的情况下,以 0.5mg/kg 剂量通过饮用水给予氟虫腈溶液(10mg/ml)对两种情况下自然发生的 PRM 感染的安全性和有效性,用于治疗鸡的 PRM。

方法

在欧洲完成了八层、两层种鸡和两层后备鸡场的盲法、阴性对照研究。在每个农场,将两个相似的鸡群饲养在相似的 PRM 污染单元(建筑物内的房间或单独的建筑物)中,每个单元的鸡数从 550 到 100,000 只不等。每个农场的一个单元被分配到氟虫腈处理,在第 0 天和第 7 天通过饮用水给药。一个单元保持未处理。在第-1、0 或 1、3、6、9 和 13 或 14 天,在每个单元中放置螨陷阱,然后每周或每两周取回一次,24 小时后处理以进行螨计数。通过与对照单元相比,从处理单元中的螨陷阱中评估每个农场的功效。还监测了生产参数和安全性。

结果

第 3 天的功效为 95.3%至 99.8%,第 9 天为 97.8%至 100%,此后在治疗开始后 56 至 238 天内保持在 90%以上。在 10 个层或种鸡场中的 9 个场,处理组的产蛋率提高了 0.9%至 12.6%。没有与治疗相关的不良事件。

结论

通过饮用水两次给予 0.5mg/kg 的氟虫腈,间隔 7 天,耐受性良好,对自然感染的鸡中的 PRM 非常有效,代表了一系列生产类型和管理系统。结果表明,这种新型治疗方法有可能成为减少或消除这种日益威胁性害虫的福利和生产力成本的综合方法的基石。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9bb/5632831/813c14360cb2/13071_2017_2390_Fig1_HTML.jpg

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