Plasencia Martínez J M, García Santos J M
Servicio de Radiología, Hospital General Universitario José M(a). Morales Meseguer, Murcia, España.
Servicio de Radiología, Hospital General Universitario José M(a). Morales Meseguer, Murcia, España.
Radiologia. 2017 Nov-Dec;59(6):478-486. doi: 10.1016/j.rx.2017.07.001. Epub 2017 Oct 7.
To establish the ability of a potential biomarker to discriminate between diseased and healthy subjects, it is essential to know the intrinsic variability of the methods used to measure the biomarker. This aspect is especially important in the ultrasonographic measurement of carotid intima-media thickness, where submillimetric variations due largely to the unrecognized lack of precision in the ultrasonographic technique can have a significant clinical impact on the classification of cardiovascular risk. This article aims to present the evidence about the reproducibility of carotid intima-media thickness measured by ultrasonography to discuss whether the variability inherent in the technique can influence the potential of this parameter as a biomarker.
为确定一种潜在生物标志物区分患病和健康受试者的能力，了解用于测量该生物标志物的方法的内在变异性至关重要。这一点在颈动脉内膜中层厚度的超声测量中尤为重要，因为在很大程度上由于超声技术未被认识到的精度不足而导致的亚毫米级变化，可能会对心血管风险分类产生重大临床影响。本文旨在展示关于超声测量颈动脉内膜中层厚度的可重复性的证据，以讨论该技术固有的变异性是否会影响此参数作为生物标志物的潜力。
