Ros Carlos, Soler Carme, García de Carellán Mateo Alejandra
Department of Small Animal Medicine and Surgery, Faculty of Veterinary Medicine, Catholic University of Valencia "San Vicente Mártir", Spain.
Department of Small Animal Medicine and Surgery, Faculty of Veterinary Medicine, Catholic University of Valencia "San Vicente Mártir", Spain.
Vet Anaesth Analg. 2017 Sep;44(5):1085-1090. doi: 10.1016/j.vaa.2016.11.007. Epub 2017 Mar 2.
To compare the effects of general anaesthesia using sevoflurane or alfaxalone on the brainstem auditory evoked response (BAER) test in adult healthy cats.
Prospective, clinical, 'blinded', crossover study.
Ten feral adult healthy cats.
Premedication consisted of dexmedetomidine (0.01 mg kg) intramuscularly (IM). The first general anaesthesia was induced and maintained with sevoflurane (treatment S) for physical examination, BAER test, complete blood tests, thoracic radiographs and abdominal ultrasound. The second general anaesthesia was induced with alfaxalone (treatment A) IM (2 mg kg) and maintained with alfaxalone (10 mg kg hour) for the BAER test, followed by neutering surgery. The BAER recordings were compared for differences in latencies, amplitudes and waveform morphology. Data were analysed using Student's t test and Wilcoxon rank test for paired samples for parametric and non-parametric data, respectively. Statistical significance was set at p < 0.05.
General anaesthesia was uneventful; normal BAER comprising five peaks could be identified in both treatments. Mean ± SD latencies were 1.05 ± 0.09, 1.83 ± 0.11, 2.52 ± 0.19, 3.43 ± 0.17 and 4.39 ± 0.15 ms and 1.03 ± 0.04, 1.81 ± 0.73, 2.53 ± 0.15, 3.37 ± 0.13 and 4.33 ± 0.13 ms in treatments S and A, respectively. Median (interquartile range) amplitudes were 2.83 (0.67), 1.27 (0.41), 0.30 (0.40), 1.05 (0.82), 0.61 (0.38) microvolts and 2.84 (1.21), 1.49 (1.18), 0.26 (0.32), 0.91 (0.50) and 0.92 (0.64) microvolts in treatments S and A, respectively. There were no statistically significant differences in mean latencies or median amplitudes between both the anaesthetics.
This study demonstrates that there were no statistically significant differences between both the anaesthetics on the BAER test in adult healthy cats. Moreover, two possible anaesthetic protocols are described for cats undergoing this electrodiagnostic test.
比较七氟醚或阿法沙龙全身麻醉对成年健康猫脑干听觉诱发电位（BAER）测试的影响。
前瞻性、临床、“盲法”、交叉研究。
十只成年野生健康猫。
术前用药为肌肉注射右美托咪定（0.01 mg/kg）。首次全身麻醉采用七氟醚诱导并维持（治疗组S），用于体格检查、BAER测试、全血细胞计数、胸部X光片和腹部超声检查。第二次全身麻醉采用肌肉注射阿法沙龙（2 mg/kg）诱导（治疗组A），并以阿法沙龙（10 mg·kg⁻¹·小时⁻¹）维持用于BAER测试，随后进行去势手术。比较两组BAER记录的潜伏期、波幅和波形形态差异。分别使用学生t检验和配对样本的Wilcoxon秩和检验对参数数据和非参数数据进行分析。设定统计学显著性水平为p < 0.05。
全身麻醉过程顺利；两种治疗方法均能识别出包含五个波峰的正常BAER。治疗组S的平均±标准差潜伏期分别为1.05±0.09、1.83±0.11、2.52±0.19、3.43±0.17和4.39±0.15 ms，治疗组A分别为1.03±0.04、1.81±0.73、2.53±0.15、3.37±0.13和4.33±0.13 ms。治疗组S的中位数（四分位间距）波幅分别为2.83（0.67）、1.27（0.41）、0.30（0.40）、1.05（0.82）、0.61（0.38）微伏，治疗组A分别为2.84（1.21）、1.49（1.18）、0.26（0.32）、0.91（0.50）和0.92（0.64）微伏。两种麻醉剂之间的平均潜伏期或中位数波幅均无统计学显著差异。
本研究表明，两种麻醉剂对成年健康猫BAER测试的影响无统计学显著差异。此外，还描述了两种适用于接受该电诊断测试的猫的麻醉方案。
