Departamento de Medicina y Cirugía Animal, Facultad de Veterinaria, Universidad Católica de Valencia, San Vicente Mártir, Valencia, Spain (García de Carellán Mateo, Ros); Hospital Veterinario Universidad Católica de Valencia San Vicente Mártir, Avenida Pérez Galdós 51, Valencia, Spain. PC: 46018 (Ríos Álvarez).
Can Vet J. 2020 Nov;61(11):1175-1180.
This study compared the quality of sedation with dexmedetomidine or alfaxalone during brainstem auditory-evoked response (BAER) tests in 6- to 17-week-old dogs. This was a prospective, randomized clinical study involving 19 client-owned pediatric dogs of breeds with reported congenital deafness. Group A (G) received alfaxalone, 2 mg/kg body weight (BW) ( = 9) and group D (G) dexmedetomidine, 0.005 mg/kg BW, and postprocedure antagonism with atipamezole ( = 10) intramuscularly. Time from injection to sedation, duration of sedation, sedation scores, need for re-dosing, rectal temperature, pulse and respiratory rate were recorded at baseline, before and after the BAER test, and once recovered from sedation. Pulse rate was significantly lower in G ( = 0.004) and the number of re-dosing was significantly higher in G ( = 0.011). Both sedation protocols allowed good quality BAER test recordings in pediatric dogs. Sedation with dexmedetomidine required less re-dosing, whereas alfaxalone maintained more physiological pulse rates.
本研究比较了在 6 至 17 周龄犬的脑干听觉诱发电位（BAER）测试中使用右美托咪定或苯环己哌啶进行镇静的效果。这是一项前瞻性、随机临床试验，涉及 19 只患有遗传性耳聋的犬。A 组（G）给予苯环己哌啶 2mg/kg 体重（BW）（=9），D 组（G）给予右美托咪定 0.005mg/kg BW，术后肌肉注射阿替美唑拮抗（=10）。在基线、BAER 测试前后和镇静恢复后记录从注射到镇静、镇静持续时间、镇静评分、需要再次给药、直肠温度、脉搏和呼吸频率。G 组的脉搏率显著降低（=0.004），G 组需要再次给药的次数显著增加（=0.011）。两种镇静方案均可在儿科犬中获得高质量的 BAER 测试记录。使用右美托咪定进行镇静需要较少的再次给药，而苯环己哌啶则保持更高的生理脉搏率。
