[α-和β-肾上腺素能受体阻滞剂对不同年龄大鼠甲状腺功能的影响]

[Effect of alpha- and beta-adrenoreceptor blockaders on thyroid function in rats of various ages].

作者信息

Gorban' E N

出版信息

Probl Endokrinol (Mosk). 1988 Mar-Apr;34(2):55-8.

Abstract

The effect of alpha-adrenoblocker dibenamine and beta-adrenoblocker propranolol on the blood level of thyroid hormones (TH) and TH production by isolated thyroids (T) was investigated in adult and old male rats. Isolated T were incubated for 4 h in medium 199 with or without TSH (100 mU/ml). TH blood concentration and specific TH production by isolated T was decreased with age. TSH stimulated thyroid hormone production in isolated T only in adult rats. Alpha- or beta-adrenoblockers administration resulted in a decrease in the TH blood concentration, basal and TSH-stimulated thyroid hormone production in adult rats. The results obtained suggested that aging was accompanied by decreased adrenergic control of thyroid function.

摘要

在成年和老年雄性大鼠中，研究了α-肾上腺素能阻滞剂二苯胺和β-肾上腺素能阻滞剂普萘洛尔对甲状腺激素（TH）血药浓度以及离体甲状腺（T）甲状腺激素分泌的影响。将离体甲状腺在含或不含促甲状腺激素（TSH，100 mU/ml）的199培养基中孵育4小时。随着年龄增长，TH血药浓度和离体甲状腺的甲状腺激素分泌减少。TSH仅刺激成年大鼠离体甲状腺的甲状腺激素分泌。给予α-或β-肾上腺素能阻滞剂会导致成年大鼠TH血药浓度、基础甲状腺激素分泌以及TSH刺激的甲状腺激素分泌减少。研究结果表明，衰老伴随着甲状腺功能的肾上腺素能控制减弱。