Department of Pediatrics, Baylor College of Medicine, 1100 Bates Avenue, Houston, TX 77030, USA.
J Steroid Biochem Mol Biol. 2018 Mar;177:125-128. doi: 10.1016/j.jsbmb.2017.10.005. Epub 2017 Oct 6.
Vitamin D deficiency is linked to type 2 diabetes and we recently showed this may be through action of vitamin D in the paraventricular nuclei (PVN) in the hypothalamus of the brain. This review focuses on the known roles of the PVN in glucose control and how previously discovered actions of vitamin D in other tissues may translate to action in the PVN. Specifically, we focus on the role of insulin and inflammation in the hypothalamus and how these may be modified through vitamin D action.
维生素 D 缺乏与 2 型糖尿病有关，我们最近的研究表明，这可能是通过维生素 D 在大脑下丘脑室旁核 (PVN)中的作用。本综述重点介绍了 PVN 在葡萄糖控制中的已知作用，以及先前在其他组织中发现的维生素 D 作用如何转化为在 PVN 中的作用。具体而言，我们重点研究了胰岛素和炎症在下丘脑的作用，以及维生素 D 作用如何改变这些作用。
