培氟沙星和 10 种对照抗菌药物对 502 株从皮肤和皮肤结构感染中分离出的厌氧菌的活性。
Activities of Pexiganan and 10 Comparator Antimicrobials against 502 Anaerobic Isolates Recovered from Skin and Skin Structure Infections.
机构信息
R. M. Alden Research Laboratory, Culver City, California, USA
David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
出版信息
Antimicrob Agents Chemother. 2017 Nov 22;61(12). doi: 10.1128/AAC.01401-17. Print 2017 Dec.
Abstract
Pexiganan, a cationic peptide, exhibited a broad range of anti-anaerobic antimicrobial activity. The MICs of studied isolates were as follows: , 16 μg/ml; other group spp., 4 μg/ml; and spp., 32 μg/ml; spp., 64 μg/ml; , 4 μg/ml; and , 32 μg/ml; other Gram-positive rods and cocci, 4 μg/ml; , 128 μg/ml; and other clostridia, 256 μg/ml. Pexiganan cream shows potential as adjunctive therapy for skin and skin structure infections (SSSIs) involving anaerobes.
摘要
培氟沙星，一种阳离子肽，表现出广谱抗厌氧抗菌活性。研究分离株的 MIC 如下： ，16 μg/ml；其他 组 spp.，4 μg/ml； 和 spp.，32 μg/ml； spp.，64 μg/ml； ，4 μg/ml； 和 ，32 μg/ml；其他革兰氏阳性杆菌和球菌，4 μg/ml； ，128 μg/ml；和其他梭菌，256 μg/ml。培氟沙星乳膏具有作为涉及厌氧菌的皮肤和皮肤结构感染（SSSIs）辅助治疗的潜力。
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1
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2
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3
Beyond the Intensive Care Unit (ICU): Countywide Impact of Universal ICU Staphylococcus aureus Decolonization.
Am J Epidemiol. 2016 Mar 1;183(5):480-9. doi: 10.1093/aje/kww008. Epub 2016 Feb 11.
4
Differences in distribution and antimicrobial susceptibility of anaerobes isolated from complicated intra-abdominal infections versus diabetic foot infections.
Diagn Microbiol Infect Dis. 2013 Aug;76(4):546-8. doi: 10.1016/j.diagmicrobio.2013.04.025. Epub 2013 May 30.
5
Microbiology of facial cellulitis related to dental infection.
Med Mal Infect. 2011 Oct;41(10):540-5. doi: 10.1016/j.medmal.2011.01.014. Epub 2011 Sep 9.
6
Re-assessment of phenotypic identifications of Bacteroides putredinis to Alistipes species using molecular methods.
Anaerobe. 2011 Jun;17(3):130-4. doi: 10.1016/j.anaerobe.2011.04.002. Epub 2011 Apr 20.
7
Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America.
Clin Infect Dis. 2010 Jan 15;50(2):133-64. doi: 10.1086/649554.
8
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J Clin Microbiol. 2007 Sep;45(9):2819-28. doi: 10.1128/JCM.00551-07. Epub 2007 Jul 3.
9
Bacteriology of human and animal bite wounds.
J Clin Microbiol. 1978 Dec;8(6):667-72. doi: 10.1128/jcm.8.6.667-672.1978.
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