Németh Zsuzsanna, Boér Katalin, Borbély Katalin
Oncological Department, Szent Margit Kórhaz, Budapest, Hungary.
PET/CT Outpatient Department, National Institute of Oncology, Budapest, Hungary.
Pathol Oncol Res. 2019 Jan;25(1):131-136. doi: 10.1007/s12253-017-0325-0. Epub 2017 Oct 9.
The effective management of patients with sarcomas requires accurate diagnosis and staging. Imaging, such as ultrasonography (US), computed tomography (CT), magnetic resonance imaging (MRI) are the most freqently used methods for the detection of the lesion location, size, morphology and structural changes to adjacent tissues; however, these modalities provide little information about tumour biology. MRI is a robust and useful modality in tumour staging of sarcomas, however metabolic-fluorodeoxyglucose positron emission tomography/ computer tomography (F-FDG PET/CT) provides greater accuracy to overall staging in combination with MRI [1]. The advantages of F-FDG PET/CT method compared with CT and MRI is that it provides a whole body imaging, maps the viability of the tumour or the metabolic activity of the tissue. Additionally, PET detects the most agressive part of the tumour, demonstrates the biological behaviour of the tumour and therefore has a predictive value. Little data ara available on the role of F-FDG PET/CT in the management of sarcomas. The present manuscript aims to provide a review of the major indications of F-FDG PET/CT for diagnosis, staging, restaging and monitoring response to therapy and to compare its usefulness with the conventional imaging modalities in the management of patients with sarcomas.
肉瘤患者的有效管理需要准确的诊断和分期。超声检查（US）、计算机断层扫描（CT）、磁共振成像（MRI）等影像学检查是检测病变位置、大小、形态以及对相邻组织的结构变化最常用的方法；然而，这些检查方式几乎无法提供有关肿瘤生物学的信息。MRI在肉瘤的肿瘤分期中是一种强大且有用的检查方式，然而代谢型氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（F-FDG PET/CT）与MRI联合使用时，能为整体分期提供更高的准确性[1]。F-FDG PET/CT方法相较于CT和MRI的优势在于它能进行全身成像，描绘肿瘤的活性或组织的代谢活性。此外，PET能检测出肿瘤最具侵袭性的部分，展示肿瘤的生物学行为，因此具有预测价值。关于F-FDG PET/CT在肉瘤管理中的作用，现有数据较少。本手稿旨在综述F-FDG PET/CT在诊断、分期、再分期以及监测治疗反应方面的主要适应证，并比较其与传统成像方式在肉瘤患者管理中的有用性。
