Sarcoma Center, Peking University Cancer Hospital & Institute, Beijing, China.
Department of Pathology, Peking University Cancer Hospital & Institute, Beijing, China.
Contrast Media Mol Imaging. 2018 Jul 2;2018:2601281. doi: 10.1155/2018/2601281. eCollection 2018.
To assess the diagnostic value of 18F-FDG-PET/CT for different retroperitoneal soft tissue sarcomas (STS) and other similar tumors. To analyze the predictive value of 18F-FDG-PET/CT for histological grade and main prognostic factors.
195 patients with 44 different diseases have been included. Relationship between SUVmax, Clinical, pathological, and prognostic information has been analyzed.
Malignant tumors do not show higher SUVmax than benign ones (=0.443). We divided all 44 different diseases into two groups; SUVmax of group 1 is significantly higher than group 2 ( ≤ 0.001). The ROC curve suggests 4.35 is the cutoff value to distinguish groups 1 and 2 (sensitivity = 0.789; specificity = 0.736). SUVmax correlates with Ki-67 index, mitotic count, vascular resection, histological grade, and recurrent STS without considering pathological diagnosis (=0.001, =0.012, =0.002, ≤ 0.001, and =0.037, resp.).
18F-FDG-PET/CT cannot simply distinguish malignant and benign tumors in retroperitoneal/intra-abdominal cavity; however, the SUVmax of malignant tumors, inflammatory pseudotumor, and PPGL group is higher than the SUVmax of benign tumors, lymph node metastasis, hematoma, and low malignant STS group. Guidance of "SUVmax location" may be helpful for biopsy and pathology dissection.
评估 18F-FDG-PET/CT 对不同腹膜后软组织肉瘤（STS）和其他类似肿瘤的诊断价值。分析 18F-FDG-PET/CT 对组织学分级和主要预后因素的预测价值。
纳入 195 例 44 种不同疾病的患者。分析 SUVmax、临床、病理和预后信息之间的关系。
恶性肿瘤的 SUVmax 并不高于良性肿瘤（=0.443）。我们将所有 44 种不同的疾病分为两组；组 1 的 SUVmax 明显高于组 2（=0.001）。ROC 曲线提示 4.35 是区分组 1 和组 2 的截止值（敏感性=0.789；特异性=0.736）。SUVmax 与 Ki-67 指数、有丝分裂计数、血管切除、组织学分级和复发性 STS 相关，而不考虑病理诊断（=0.001、=0.012、=0.002、=0.001 和=0.037，分别）。
18F-FDG-PET/CT 不能简单地区分腹膜后/腹腔内的良恶性肿瘤；然而，恶性肿瘤、炎性假瘤和 PPGL 组的 SUVmax 高于良性肿瘤、淋巴结转移、血肿和低度恶性 STS 组的 SUVmax。“SUVmax 位置”的指导可能有助于活检和病理解剖。
