Department of Chemistry, University of Karachi, Karachi, 75270, Pakistan.
Department of Chemistry and Earth Sciences, Qatar University, Doha, Qatar.
Biometals. 2017 Dec;30(6):873-891. doi: 10.1007/s10534-017-0054-6. Epub 2017 Oct 9.
The present study explores the synthesis and inhibitory potential of vanadium(V) complexes of hydrazides (1c-12c) against oxidative enzymes including xanthine oxidase and lipoxygenase (LOX). In addition, non-enzymatic radical scavenging activities of these complexes were also determined. On the basis of spectral, elemental and physical data, synthesized vanadium(V) complexes are tentatively assigned to have an octahedral geometry with two hydrazide ligands and two oxo groups forming a negatively charged sphere complex with ammonium as counter ion. This is further verified by the conductivity studies of the complexes. Results show that hydrazide ligands (1-12) and their respective vanadium(V) complexes (1c-12c) posses scavenging and inhibition potential against DPPH and LOX, respectively. However, contrary to that uncoordinated ligands showed no activity against nitric oxide, superoxide and xanthine oxidase whereas their complexes showed varying degree of activity. These studies indicate that geometry of complex, nature and position of substituent groups play a vital role in scavenging and inhibition potential of these compounds.
本研究探索了酰腙（1c-12c）的钒（V）配合物的合成及其对黄嘌呤氧化酶和脂氧合酶（LOX）等氧化酶的抑制潜力。此外，还测定了这些配合物的非酶自由基清除活性。根据光谱、元素和物理数据，合成的钒（V）配合物被初步假定为具有八面体几何形状，两个酰腙配体和两个氧原子形成带负电荷的球体配合物，铵作为抗衡离子。这通过配合物的电导率研究得到进一步验证。结果表明，酰腙配体（1-12）及其各自的钒（V）配合物（1c-12c）分别具有对 DPPH 和 LOX 的清除和抑制作用。然而，与配位的配体不同，它们对一氧化氮、超氧自由基和黄嘌呤氧化酶没有活性，而它们的配合物则表现出不同程度的活性。这些研究表明，配合物的几何形状、取代基的性质和位置在这些化合物的清除和抑制潜力中起着至关重要的作用。
