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TIPE1 通过下调胃癌中的 Wnt/β-连环蛋白通路抑制侵袭和迁移。

TIPE1 suppresses invasion and migration through down-regulating Wnt/β-catenin pathway in gastric cancer.

机构信息

Department of Pharmacology, Shandong University School of Medicine, Jinan, China.

Taishan District Center for Disease Control and Prevention, Taian, China.

出版信息

J Cell Mol Med. 2018 Feb;22(2):1103-1117. doi: 10.1111/jcmm.13362. Epub 2017 Oct 10.

DOI:10.1111/jcmm.13362
PMID:28994231
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5783849/
Abstract

Epithelial-mesenchymal transition (EMT) plays an important role in the invasiveness and metastasis of gastric cancer. Therefore, identifying key molecules involved in EMT will provide new therapeutic strategy for treating patients with gastric cancer. TIPE1 is a newly identified member of the TIPE (TNFAIP8) family, and its contributions to progression and metastasis have not been evaluated. In this study, we found that the levels of TIPE1 were significantly reduced and inversely correlated with differentiation status and distant metastasis in primary gastric cancer tissues. We further observed overexpression of TIPE1 in aggressive gastric cancer cell lines decreased their metastatic properties both in vitro and in vivo as demonstrated by markedly inhibiting EMT and metastasis of gastric cancer cells in nude mice. Consistently, gene silencing of TIPE1 in well-differentiated gastric cancer cell line (AGS) inhibited these processes. Mechanistically, we found that TIPE1-medicated Wnt/β-catenin signalling was one of the critical signal transduction pathways that link TIPE1 to EMT inhibition. Importantly, TIPE1 dramatically restrained the expression and activities of MMP2 and MMP9 which are demonstrated to promote tumour progression and are implicated in EMT. Collectively, these findings provide new evidence for a better understanding of the biological activities of TIPE1 in progression and metastasis of gastric cancer and suggest that TIPE1 may be an innovative diagnostic and therapeutic target of gastric cancer.

摘要

上皮-间充质转化 (EMT) 在胃癌的侵袭和转移中起重要作用。因此，鉴定 EMT 中涉及的关键分子将为治疗胃癌患者提供新的治疗策略。TIPE1 是新发现的 TNFAIP8 家族的成员，其对进展和转移的贡献尚未得到评估。在这项研究中，我们发现 TIPE1 的水平在原发性胃癌组织中显著降低，与分化状态和远处转移呈负相关。我们进一步观察到，在侵袭性胃癌细胞系中过表达 TIPE1 可显著抑制 EMT 和胃癌细胞在裸鼠中的转移，从而降低其转移特性。一致地，在分化良好的胃癌细胞系（AGS）中沉默 TIPE1 基因可抑制这些过程。从机制上讲，我们发现 TIPE1 介导的 Wnt/β-catenin 信号通路是 TIPE1 与 EMT 抑制相关的关键信号转导通路之一。重要的是，TIPE1 显著抑制了 MMP2 和 MMP9 的表达和活性，这些酶被证明可促进肿瘤进展，并与 EMT 有关。总之，这些发现为更好地理解 TIPE1 在胃癌进展和转移中的生物学活性提供了新的证据，并表明 TIPE1 可能是胃癌的创新性诊断和治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc97/5783849/522245e034f3/JCMM-22-1103-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc97/5783849/df0e949ee612/JCMM-22-1103-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc97/5783849/96c88c7c94b0/JCMM-22-1103-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc97/5783849/6bb4ef7a997e/JCMM-22-1103-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc97/5783849/95b7e0188965/JCMM-22-1103-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc97/5783849/c0b7ad233a66/JCMM-22-1103-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc97/5783849/82e84f37978b/JCMM-22-1103-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc97/5783849/76be8e437e6d/JCMM-22-1103-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc97/5783849/522245e034f3/JCMM-22-1103-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc97/5783849/df0e949ee612/JCMM-22-1103-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc97/5783849/58526fc5e53e/JCMM-22-1103-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc97/5783849/96c88c7c94b0/JCMM-22-1103-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc97/5783849/6bb4ef7a997e/JCMM-22-1103-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc97/5783849/95b7e0188965/JCMM-22-1103-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc97/5783849/c0b7ad233a66/JCMM-22-1103-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc97/5783849/82e84f37978b/JCMM-22-1103-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc97/5783849/76be8e437e6d/JCMM-22-1103-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc97/5783849/522245e034f3/JCMM-22-1103-g009.jpg

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2
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Oncol Res. 2016;24(4):255-61. doi: 10.3727/096504016X14666990347356.
3
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4
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6
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9
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