Andreoni Massimo, Mussi Chiara, Bellagamba Rita, Di Campli Francesco, Montinaro Vincenzo, Babiloni Claudio
Department of Medicine of Systems, Infectious Diseases, University of Rome "Tor Vergata", Rome, Italy.
Department of Geriatrics, Nuovo Ospedale Civile S. Agostino Estense, Modena, and Reggio Emilia University, Modena, Italy.
New Microbiol. 2018 Jan;41(1):1-25. Epub 2017 Oct 10.
HIV-positive individuals are more vulnerable to poor health than HIV-negative individuals. This vulnerability is characterized by a higher risk of several common, age-related health problems, even after adjustment for established risk factors. This expert opinion report aims at identifying the optimal biomarkers for monitoring the structural integrity and function of physiological systems at risk across aging in HIV-seropositive subjects. These biomarkers, readily available locally and relatively cost-effective for clinicians in primary and secondary care, should allow early detection of the first preclinical structural and functional changes in renal, brain, cardiovascular, and skeleton systems or apparatus in HIV subjects across aging. A particular interest of this report is the definition of the concept of biomarker of the "organ functional reserve". This definition emphasizes the fact that some biomarkers for monitoring the molecular, structural and functional integrity of a given organ reflect a level of impairment that is basically irremediable despite effective pharmacological or nonpharmacological intervention.
与艾滋病毒阴性个体相比，艾滋病毒阳性个体的健康状况更易受到影响。这种易损性表现为，即使在对既定风险因素进行调整之后，出现一些常见的、与年龄相关的健康问题的风险依然更高。本专家意见报告旨在确定最佳生物标志物，以监测艾滋病毒血清阳性受试者在衰老过程中面临风险的生理系统的结构完整性和功能。这些生物标志物在当地易于获取，且对初级和二级护理中的临床医生来说成本相对较低，应能使我们早期检测出艾滋病毒感染者在衰老过程中肾脏、大脑、心血管和骨骼系统或器官出现的首次临床前结构和功能变化。本报告特别关注的是“器官功能储备”生物标志物概念的定义。这一定义强调了这样一个事实，即一些用于监测特定器官分子、结构和功能完整性的生物标志物所反映的损伤程度，即便采取有效的药物或非药物干预基本上也无法补救。
