在有血清和无血清情况下米卡芬净对白色念珠菌、都柏林念珠菌和非洲念珠菌的抗真菌后效应
Postantifungal effect of micafungin against Candida albicans, Candida dubliniensis and Candida africana in the presence and absence of serum.
作者信息
Kardos Tamás, Saleh Qasem, Kovács Renátó, Gesztelyi Rudolf, Kardos Gábor, Bozó Aliz, Tóth Zoltán, Majoros László
机构信息
University of Debrecen, Faculty of Medicine, Department of Pulmonology, Hungary.
University of Debrecen, Faculty of Medicine, Medical Microbiology, Hungary.
出版信息
New Microbiol. 2017 Oct;40(4):286-288. Epub 2017 Oct 10.
We compared the micafungin killing rate and postantifungal effect (PAFE) at 4, 16 and 32 mg/L in RPMI- 1640 and in 50% serum against the C. albicans complex. In RPMI-1640 PAFEs were 1.5 - >19.4, 9.7 - >20.1 and 15.9 - >18.5 hours for C. albicans, C. africana and C. dubliniensis, respectively. In 50% serum PAFEs decreased sharply to 0-1.7 hours for all three species; killing rates were always negative. Short growth inhibition without killing in 50% serum suggests that micafungin PAFE has a limited role in the eradication of the C. albicans complex from the bloodstream.
我们比较了米卡芬净在RPMI-1640培养基以及含50%血清的培养基中，浓度为4、16和32mg/L时对白色念珠菌复合体的杀菌率和抗真菌后效应（PAFE）。在RPMI-1640培养基中，白色念珠菌、非洲念珠菌和都柏林念珠菌的PAFE分别为1.5至大于19.4小时、9.7至大于20.1小时以及15.9至大于18.5小时。在含50%血清的培养基中，这三种念珠菌的PAFE均急剧降至0至1.7小时；杀菌率始终为负。在50%血清中出现短暂的生长抑制但无杀灭作用，这表明米卡芬净的PAFE在从血流中根除白色念珠菌复合体方面作用有限。
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