Yu Wenxin, Zhu Jiafang, Changc Shih-Jen, Chen Hui, Jin Yunbo, Yang Xi, Wang Tianyou, Chang Lei, Chen Yijie, Ma Gang, Lin Xiaoxi
Department of Plastic and Reconstructive Surgery, Laser Center, Shanghai Ninth People's Hospital, Shanghai Jiaotong University , School of Medicine, Shanghai, China .
Photomed Laser Surg. 2018 Jan;36(1):37-43. doi: 10.1089/pho.2017.4315. Epub 2017 Oct 10.
To compare the safety and efficacy of pulsed dye laser (PDL) at different intervals for the treatment of East Asians with Port-Wine Stain (PWS).
The population of East Asians around the world is about 1.6 billion, and they are considered to have more melanin in their skin compared with Caucasians. Nevertheless, no studies about the optimal treatment intervals for East Asians with PWS have been carried out.
We prospectively investigated 39 East Asian patients with untreated PWS. Half of the PWS lesion was randomly allocated to be treated at 3 weeks and the other half at 6 weeks. Both halves of the PWS were treated three times in total. The efficacy outcome 2 months post final treatment was evaluated by visual and chromameter evaluation.
The average blanching rate was 40.27% and 44.17% for PDL treatments at the 3- and 6-week interval sites, respectively (p > 0.05). No patient developed scarring or permanent pigmentation change.
There was no age criteria involved in the enrollment of patients in this study. Additionally, there is no comparison with long-term treatments at different intervals.
PDL treatment at 3-week interval proved to be safe for East Asians with PWS. This can reduce the total duration of the course of treatments and had no increase in side effects compared with the standard interval treatments.
比较不同间隔时间的脉冲染料激光（PDL）治疗东亚人葡萄酒色斑（PWS）的安全性和疗效。
全球东亚人口约16亿，与白种人相比，他们被认为皮肤中黑色素更多。然而，尚未有关于东亚PWS患者最佳治疗间隔时间的研究。
我们前瞻性地研究了39例未经治疗的东亚PWS患者。PWS皮损的一半随机分配在3周时治疗，另一半在6周时治疗。PWS的两半总共治疗3次。末次治疗后2个月通过视觉和色差仪评估疗效结果。
3周和6周间隔部位的PDL治疗平均褪色率分别为40.27%和44.17%（p>0.05）。没有患者出现瘢痕或永久性色素沉着改变。
本研究患者入组未涉及年龄标准。此外，未对不同间隔的长期治疗进行比较。
对于东亚PWS患者，3周间隔的PDL治疗被证明是安全的。与标准间隔治疗相比，这可以缩短治疗疗程的总时长且不增加副作用。
