Sheng Hao, Zeng Hui, Zhang Meng
Department of Dermatology, Wuhan Puren Hospital, Qingshan District, Wuhan, Hubei Province, China.
Outpatient Department of Wuhan Mental Health Centre, Jiang'an District, Wuhan, Hubei Province, China.
Postepy Dermatol Alergol. 2022 Oct;39(5):923-927. doi: 10.5114/ada.2022.119073. Epub 2022 Sep 6.
One of the most common congenital vascular abnormalities in the dermal area of the skin is the port-wine stain (PWS).
Researchers are trying to introduce more effective new methods of treatment of PWS.
This clinical trial study was conducted on 60 patients in Huanggang Central Hospital during May 2020 to June 2021. Pulsed dye laser (PDL) only and PDL plus CO2 methods were used to treat PWS, the clearance scores of patients were assessed for both methods, and the side effects were examined.
The mean age of the patients was 26.87 ±9.67 years. The majority of the patients (80%) were female. Thirty-four (56.66%) patients had PWS in the malar area, 14 (23.33%) on their forehead, 5 (8.33%) on their chin, and 7 (11.7%) on neck. The efficacy of the treatment through clearance score shows that the quantitative mean of the clearance score of the patients in the PDL method was 2.71 ±0.54, and in the CO2 + PDL method it was 2.72 ±0.56 ( > 0.05). The qualitative comparison of clearance scores indicated that in the PDL method, 18 (30%) patients had acceptable clearance, 30 (50%) patients had good clearance, and 12 (20%) patients had excellent clearance. Also, for the PDL plus CO method, 25 (41.766) patients had acceptable clearance, 23 (38.34%) patients had good clearance, and 12 (20%) patients had excellent clearance.
For PWS patients under treatment with PDL plus CO, the hyperpigmentation side effect was greater than in patients with underlying PDL only.
皮肤真皮层最常见的先天性血管异常之一是葡萄酒色斑（PWS）。
研究人员正试图引入更有效的PWS治疗新方法。
2020年5月至2021年6月期间，在黄冈市中心医院对60例患者进行了这项临床试验研究。采用单纯脉冲染料激光（PDL）和PDL联合CO2方法治疗PWS，评估两种方法患者的清除率评分，并检查副作用。
患者的平均年龄为26.87±9.67岁。大多数患者（80%）为女性。34例（56.66%）患者的PWS位于颧部，14例（23.33%）在前额，5例（8.33%）在下巴，7例（11.7%）在颈部。通过清除率评分评估治疗效果显示，PDL方法患者清除率评分的定量平均值为2.71±0.54，CO2+PDL方法为2.72±0.56（>0.05）。清除率评分的定性比较表明，PDL方法中，18例（30%）患者清除效果可接受，30例（50%）患者清除效果良好，12例（20%）患者清除效果极佳。同样，对于PDL联合CO方法，25例（41.766）患者清除效果可接受，23例（38.34%）患者清除效果良好，12例（20%）患者清除效果极佳。
对于接受PDL联合CO治疗的PWS患者，色素沉着副作用比仅接受基础PDL治疗的患者更大。
