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一种提高从体外循环回路中抽吸挥发性麻醉剂安全性的创新技术。

An innovative technique to improve safety of volatile anesthetics suction from the cardiopulmonary bypass circuit.

作者信息

De Simone Francesco, Cassarà Luigi, Sardo Salvatore, Scarparo Elena, Saleh Omar, Nigro Neto Caetano, Zangrillo Alberto, Landoni Giovanni

机构信息

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.

出版信息

Ann Card Anaesth. 2017 Oct-Dec;20(4):399-402. doi: 10.4103/aca.ACA_50_17.

DOI:10.4103/aca.ACA_50_17
PMID:28994673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5661307/
Abstract

CONTEXT

Myocardial injury during cardiac surgery on cardiopulmonary bypass (CPB) is a major determinant of morbidity and mortality. Preclinical and clinical evidence of dose- and time-related cardioprotective effects of volatile anesthetic drugs exist and their use during the whole surgery duration could improve perioperative cardiac protection. Even if administering volatile agents during CPB are relatively easy, technical problems, such as waste gas scavenging, may prevent safe and manageable administration of halogenated vapors during CPB.

AIMS

The aim of this study is to improve the safe administration of volatile anesthesia during CPB.

SETTINGS AND DESIGN

Tertiary teaching hospital.

SUBJECTS AND METHODS

We describe an original device that collects and disposes of any volatile anesthetic vapors present in the exit stream of the oxygenator, hence preventing its dispersal into the operating theatre environment and adaptively regulates pressure of oxygenator chamber in the CPB circuit.

RESULTS

We have so far applied a prototype of this device in more than 1300 adult cardiac surgery patients who received volatile anesthetics during the CPB phase.

CONCLUSIONS

Widespread implementation of scavenging system like the one we designed may facilitate the perfusionist and the anesthesiologist in delivering these cardioprotective drugs with beneficial impact on patients' outcome without compromising on safety.

摘要

背景

体外循环(CPB)心脏手术期间的心肌损伤是发病率和死亡率的主要决定因素。挥发性麻醉药物存在剂量和时间相关的心脏保护作用的临床前和临床证据,在整个手术过程中使用这些药物可能会改善围手术期的心脏保护。即使在CPB期间给予挥发性药物相对容易,但诸如废气清除等技术问题可能会妨碍在CPB期间安全且可管理地给予卤化蒸汽。

目的

本研究的目的是改善CPB期间挥发性麻醉的安全给药。

设置与设计

三级教学医院。

对象与方法

我们描述了一种原始装置,该装置收集并处理氧合器出口气流中存在的任何挥发性麻醉蒸汽,从而防止其扩散到手术室环境中,并能自适应调节CPB回路中氧合器腔室的压力。

结果

到目前为止,我们已将该装置的原型应用于1300多名在CPB阶段接受挥发性麻醉的成年心脏手术患者。

结论

像我们设计的这种清除系统的广泛实施可能会帮助灌注师和麻醉师在不影响安全性的情况下给予这些具有心脏保护作用的药物,对患者的预后产生有益影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9c7/5661307/a89a7325cf72/ACA-20-399-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9c7/5661307/ca126fd98224/ACA-20-399-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9c7/5661307/850b5be92a9e/ACA-20-399-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9c7/5661307/a89a7325cf72/ACA-20-399-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9c7/5661307/ca126fd98224/ACA-20-399-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9c7/5661307/850b5be92a9e/ACA-20-399-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9c7/5661307/a89a7325cf72/ACA-20-399-g003.jpg

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本文引用的文献

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J Cardiothorac Vasc Anesth. 2017 Aug;31(4):1210-1217. doi: 10.1053/j.jvca.2016.12.018. Epub 2016 Dec 18.
2
Randomized Evidence for Reduction of Perioperative Mortality: An Updated Consensus Process.降低围手术期死亡率的随机证据:更新的共识过程。
J Cardiothorac Vasc Anesth. 2017 Apr;31(2):719-730. doi: 10.1053/j.jvca.2016.07.017. Epub 2016 Aug 2.
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Additive Effect on Survival of Anaesthetic Cardiac Protection and Remote Ischemic Preconditioning in Cardiac Surgery: A Bayesian Network Meta-Analysis of Randomized Trials.
心脏手术室中的大气污染。
Ann Card Anaesth. 2017 Oct-Dec;20(4):391-392. doi: 10.4103/aca.ACA_126_17.
麻醉心脏保护与远程缺血预处理对心脏手术患者生存的叠加效应:一项随机试验的贝叶斯网络荟萃分析
PLoS One. 2015 Jul 31;10(7):e0134264. doi: 10.1371/journal.pone.0134264. eCollection 2015.
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Volatile anesthetic-induced cardiac protection: molecular mechanisms, clinical aspects, and interactions with nonvolatile agents.挥发性麻醉药诱导的心脏保护:分子机制、临床方面以及与非挥发性药物的相互作用。
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Perfusion. 2015 Jan;30(1):6-16. doi: 10.1177/0267659114531314. Epub 2014 Apr 14.
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