有袋类动物转铁蛋白的铁结合特性及氨基酸组成：与真兽类哺乳动物和其他脊椎动物的比较。

Iron-binding properties and amino acid composition of marsupial transferrins: comparison with eutherian mammals and other vertebrates.

Lim B C, Peters T, Morgan E H

Department of Physiology, University of Western Australia, Nedlands.

Comp Biochem Physiol A Comp Physiol. 1988;89(4):559-65. doi: 10.1016/0300-9629(88)90833-x.

Abstract

Some physicochemical properties of transferrin from three marsupials, viz a possum (Trachosurus vulpecula), a kangaroo (Macropus fuliginosus) and the quokka (Setonix brachyurus) were studied and compared with those of transferrins from mammalian and non-mammalian vertebrate species. 2. The molecular weight of the marsupial transferrins fell within the range of 76,000-79,000 daltons. 3. The marsupial transferrins were similar to the transferrins of eutherian mammals with respect to optical spectral properties, iron binding capacity and the pH-dependence of iron binding, and iron release mediated by 2,3-DPG. 4. The amino acid compositions of the marsupial transferrins were compared with each other and with the transferrins from the other vertebrate species. The compositions of the marsupial transferrin were closely related to each other, and also showed similarities with transferrins from eutherian mammals and chicken ovotransferrin.

摘要

研究了三种有袋动物（即负鼠（帚尾袋貂）、袋鼠（黑大袋鼠）和短尾矮袋鼠）的转铁蛋白的一些物理化学性质，并与哺乳动物和非哺乳动物脊椎动物物种的转铁蛋白性质进行了比较。2. 有袋动物转铁蛋白的分子量在76,000 - 79,000道尔顿范围内。3. 在光谱特性、铁结合能力、铁结合的pH依赖性以及由2,3 - 二磷酸甘油酸介导的铁释放方面，有袋动物转铁蛋白与真兽类哺乳动物的转铁蛋白相似。4. 比较了有袋动物转铁蛋白彼此之间以及与其他脊椎动物物种转铁蛋白的氨基酸组成。有袋动物转铁蛋白的组成彼此密切相关，并且与真兽类哺乳动物的转铁蛋白和鸡卵转铁蛋白也有相似之处。