胆囊收缩素肽对青鳉体内消化酶的影响。

Effects of cholecystokinin peptides on digestive enzymes in killifish in vivo.

Honkanen R E, Crim J W, Patton J S

Department of Microbiology, University of Georgia, Athens 30602.

Comp Biochem Physiol A Comp Physiol. 1988;89(4):655-60. doi: 10.1016/0300-9629(88)90849-3.

Abstract

The abilities of cholecystokinin-like peptides to elicit lipase secretion were examined in the stomachless killifish, Fundulus heteroclitus. 2. Cholecystokinin octapeptide, caerulein, and nonsulfated caerulein stimulated lipase secretion in vivo, with caerulein and nonsulfated caerulein being the most potent peptides tested. 3. Lipase secretion was not induced by carbachol, and peptide stimulated lipase secretion was not inhibited by atropine. 4. These data suggest digestive enzyme secretion constitutes an evolutionary primitive role for CCK.

摘要

在无胃鳉鱼（Fundulus heteroclitus）中研究了胆囊收缩素样肽引发脂肪酶分泌的能力。2. 八肽胆囊收缩素、蛙皮素和去硫酸化蛙皮素在体内刺激脂肪酶分泌，蛙皮素和去硫酸化蛙皮素是所测试的最有效的肽。3. 卡巴胆碱未诱导脂肪酶分泌，且肽刺激的脂肪酶分泌不受阿托品抑制。4. 这些数据表明消化酶分泌是胆囊收缩素的一种进化原始作用。