Zetler G, Mörsdorf K H
Naunyn Schmiedebergs Arch Pharmacol. 1984 Mar;325(3):209-13. doi: 10.1007/BF00495945.
Subcutaneous (SC) injections of ceruletide (caerulein diethylammonium hydrate, CER) and the octapeptide of cholecystokinin (CCK-8) reduced the intake of liquid food in male NMRI mice starved for 18 h. The corresponding ED50 values were 2 micrograms/kg for CER and 24 micrograms/kg for CCK-8; hence, on a molar basis, CER was 14 times more potent than CCK-8. Naloxone (0.2 and 1 mg/kg, SC) inhibited eating. (D-Ala)2(MePhe)4-(Met(O)-ol)5-enkephalin (FK 33-824; 0.3 and 1 mg/kg) was only stimulatory. Naloxone enhanced the effect of CER, whereas FK 33-824 antagonized it. It is concluded that concerning the inhibition of food intake, opioid peptides can be antagonists of CCK-like peptides. This is consistent with the current view of the regulation of appetitive behaviour.
皮下注射蛙皮素（蛙皮素二乙铵水合物，CER）和胆囊收缩素八肽（CCK - 8）可减少饥饿18小时的雄性NMRI小鼠的流食摄入量。相应的半数有效剂量（ED50）值，CER为2微克/千克，CCK - 8为24微克/千克；因此，按摩尔计算，CER的效力是CCK - 8的14倍。纳洛酮（0.2和1毫克/千克，皮下注射）抑制进食。（D - 丙氨酸）2（甲基苯丙氨酸）4 - （甲硫氨酸（氧） - 醇）5 - 脑啡肽（FK 33 - 824；0.3和1毫克/千克）仅具有刺激作用。纳洛酮增强了CER的作用，而FK 33 - 824则拮抗其作用。得出的结论是，关于食物摄入的抑制，阿片肽可以是CCK样肽的拮抗剂。这与当前对食欲行为调节的观点一致。
