禁食和再喂养对兔胃黏膜生长抑素浓度及与胞质溶胶结合的影响。
Effects of fasting and refeeding on somatostatin concentration and binding to cytosol from rabbit gastric mucosa.
作者信息
Roca B, Fernandez-Valencia R, Arilla E
机构信息
Departamento de Bioquímica y Biologia Molecular, Facultad de Medicina, Universidad de Alcalá de Henares, Madrid, Spain.
出版信息
Gut. 1988 May;29(5):642-6. doi: 10.1136/gut.29.5.642.
Abstract
Somatostatin like immunoreactivity and the density of somatostatin binding sites were measured in stomach (fundus and antrum) from either fed, 12 to 96 hours fasted, or 96 hours fasted plus 48 hours refed rabbits. The somatostatin concentration increased in fundic and antral mucosa after 24 h and reached its highest value after 96 h of fasting. The number of specific somatostatin binding sites with high and low affinity decreased with the duration of fasting. Refeeding of fasted animals resulted in a normalisation to control values of gastric mucosal somatostatin and somatostatin binding.
摘要
在喂食、禁食12至96小时或禁食96小时加再喂食48小时的兔子的胃（胃底和胃窦）中，测量了生长抑素样免疫反应性和生长抑素结合位点的密度。禁食24小时后，胃底和胃窦黏膜中的生长抑素浓度升高，并在禁食96小时后达到最高值。具有高亲和力和低亲和力的特异性生长抑素结合位点的数量随禁食时间的延长而减少。对禁食动物再喂食导致胃黏膜生长抑素和生长抑素结合恢复到对照值。
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