Khatkhatay M I, Sankolli G M, Meherji P K, Chowdhury V, Joshi U M
Institute for Research in Reproduction (ICMR), Parel, Bombay, India.
Int J Fertil. 1988 May-Jun;33(3):181-7.
Response of the ovary to ovulation-inducing agents, such as clomiphene citrate and gonadotropin, was assessed using estimations of urinary estrone-3-glucuronide (E1G) by an ELISA test. Baseline data collected over 58 cycles from regularly menstruating women were used as reference. Further, the pattern of E1G excretion was compared with ultrasound assessment of follicular growth. In ovulatory cycles, a good correlation is seen between follicular growth and follicular function. However, when cystic follicles develop after treatment, the correlation is poor: the follicle increases in size without a corresponding increase in E1G excretion. It is suggested that ultrasound examination and hormonal pattern should be used concurrently to assess the response of the ovary to ovulation-inducing agents.
通过酶联免疫吸附测定法（ELISA）对尿雌酮-3-葡萄糖醛酸苷（E1G）进行测定，以此评估卵巢对促排卵药物（如克罗米芬柠檬酸盐和促性腺激素）的反应。从月经规律的女性中收集的58个周期的基线数据用作参考。此外，还将E1G排泄模式与卵泡生长的超声评估进行了比较。在排卵周期中，卵泡生长与卵泡功能之间存在良好的相关性。然而，治疗后出现囊性卵泡时，相关性较差：卵泡大小增加，但E1G排泄没有相应增加。建议同时使用超声检查和激素模式来评估卵巢对促排卵药物的反应。
