Hayek L J, Emerson J M, Gardner A M
Department of Microbiology, Torbay Hospital, Devon, UK.
J Hosp Infect. 1987 Sep;10(2):165-72. doi: 10.1016/0195-6701(87)90143-5.
The effect of preoperative whole-body washing with chlorhexidine detergent on the incidence of postoperative wound infection was assessed in a placebo-controlled trial of 1989 patients. Patients bathed or showered with chlorhexidine, placebo, or conventional bar soap, on two occasions in the 24 h before operation. The overall infection rate for patients treated with chlorhexidine was 9%, against 12.8% in the bar soap and 11.7% in the placebo groups; in the 'clean' surgery group infections were 7.2% against 10.2% and 10%, respectively. The Staphylococcus aureus infection rate in the 'clean' group was 3% for chlorhexidine against 6% for bar soap.
在一项针对1989例患者的安慰剂对照试验中，评估了术前用氯己定洗涤剂进行全身清洗对术后伤口感染发生率的影响。患者在手术前24小时内分两次用氯己定、安慰剂或传统香皂进行沐浴或淋浴。用氯己定治疗的患者总体感染率为9%，香皂组为12.8%，安慰剂组为11.7%；在“清洁”手术组中，感染率分别为7.2%、10.2%和10%。“清洁”组中金黄色葡萄球菌感染率，氯己定组为3%，香皂组为6%。
