Sack G H
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Mol Biol Med. 1988 Apr;5(2):61-7.
Novel structural changes in members of the serum amyloid A (SAA) gene family have been found in four patients of varied ethnic backgrounds with familial Mediterranean fever. Since the genes for these small acute phase proteins are generally well conserved, these observations suggest that alterations of serum amyloid A genes, their protein products and/or their regulation may be responsible for familial Mediterranean fever.
在四名不同种族背景的家族性地中海热患者中发现了血清淀粉样蛋白A（SAA）基因家族成员的新型结构变化。由于这些小急性期蛋白的基因通常高度保守，这些观察结果表明血清淀粉样蛋白A基因、其蛋白产物和/或其调控的改变可能是家族性地中海热的病因。
