Shirley D G, Skinner J, Walter S J
Department of Physiology, Charing Cross & Westminster Medical School, London, UK.
J Pharm Pharmacol. 1988 Apr;40(4):286-7. doi: 10.1111/j.2042-7158.1988.tb05246.x.
The effect of chronic hydrochlorothiazide administration on the composition of renal papillary interstitial fluid was investigated in the rat. Hydrochlorothiazide alone had no effect on papillary composition. However, when the sodium depletion that usually accompanies thiazide treatment was minimized by allowing the rats access to hypertonic NaCl solution, hydrochlorothiazide administration resulted in significant reductions in papillary osmolality, and sodium and potassium concentrations. It is suggested that the effects of hydrochlorothiazide on the renal papilla might be mediated by thiazide-induced hypokalaemia, and that under normal circumstances these effects are masked by the concomitant sodium depletion.
在大鼠中研究了长期给予氢氯噻嗪对肾乳头间质液成分的影响。单独使用氢氯噻嗪对乳头成分无影响。然而，当通过让大鼠饮用高渗氯化钠溶液将通常伴随噻嗪类治疗的钠耗竭降至最低时，给予氢氯噻嗪会导致乳头渗透压、钠和钾浓度显著降低。提示氢氯噻嗪对肾乳头的作用可能由噻嗪类诱导的低钾血症介导，且在正常情况下这些作用被伴随的钠耗竭所掩盖。
