Weatherall D J, Old J M, Thein S L, Wainscoat J S
Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, U.K.
Philos Trans R Soc Lond B Biol Sci. 1988 Jun 15;319(1194):249-61. doi: 10.1098/rstb.1988.0047.
The application of recombinant DNA technology to the study of human genetic disease promises to increase the scope for carrier detection and prenatal diagnosis. Here we summarize current experience with prenatal diagnosis of single-gene disorders by DNA analysis and highlight some of the technical and organizational problems that remain to be solved.
将重组DNA技术应用于人类遗传病研究有望扩大携带者检测和产前诊断的范围。在此，我们总结了目前通过DNA分析进行单基因疾病产前诊断的经验，并强调了一些有待解决的技术和组织问题。
