Kambam J R, Dymond R, Krestow M, Handte R E
King Fahad Hospital, Riyadh, Saudi Arabia.
South Med J. 1988 Aug;81(8):1013-5. doi: 10.1097/00007611-198808000-00018.
We studied the effects of preoperative administration of histamine (H1 and H2) receptor blockers on hemodynamic changes in two groups of patients having operation for hydatid cyst. Patients in group 1 received no antihistaminics, whereas those in group 2 were pretreated with both H1 (diphenhydramine) and H2 (cimetidine) receptor blockers. Even though there were significant hemodynamic responses associated with spillage of hydatid cyst contents in both groups, the hemodynamic changes were significantly less in the patients who had received histamine receptor blockers. We conclude that the preoperative administration of H1 and H2 receptor blockers to patients having hydatid cyst surgery is beneficial.
我们研究了术前给予组胺（H1和H2）受体阻滞剂对两组包虫囊肿手术患者血流动力学变化的影响。第1组患者未接受抗组胺药治疗，而第2组患者则同时接受H1（苯海拉明）和H2（西咪替丁）受体阻滞剂预处理。尽管两组患者因包虫囊肿内容物溢出均出现了显著的血流动力学反应，但接受组胺受体阻滞剂治疗的患者血流动力学变化明显较小。我们得出结论，对行包虫囊肿手术的患者术前给予H1和H2受体阻滞剂是有益的。
