Murphy J J, Hampton J R
Department of Medicine, University Hospital, Nottingham.
Br Heart J. 1988 Jul;60(1):45-9. doi: 10.1136/hrt.60.1.45.
Ten patients with chronic heart failure were given a continuous infusion of dopexamine after an initial stage of dose titration. On the dose selected the cardiac index initially rose by 56%, as a result of an increase in both heart rate and stroke volume index. Systemic vascular resistance fell by 34% and the mean arterial pressure did not change. Within 18 hours of the start of the continuous infusion, however, all the variables except heart rate had returned to preinfusion values. Nine of the 10 patients were withdrawn from the 48 hour study, six because of haemodynamic deterioration and two because of side effects. If the premature loss of therapeutic effect reflects an intrinsic property of this agent, dopexamine may be of limited clinical value.
10例慢性心力衰竭患者在初始剂量滴定阶段后持续输注多培沙明。在选定的剂量下，心脏指数最初上升了56%，这是心率和每搏量指数增加的结果。全身血管阻力下降了34%，平均动脉压未发生变化。然而，在持续输注开始后的18小时内，除心率外的所有变量均恢复到输注前的值。10例患者中有9例退出了48小时的研究，6例因血流动力学恶化，2例因副作用。如果治疗效果过早丧失反映了该药物的内在特性，那么多培沙明的临床价值可能有限。
