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Enalapril reduces the catecholamine response to exercise in patients with heart failure.

作者信息

McGrath B P, Arnolda L F

出版信息

Eur J Clin Pharmacol. 1986;30(4):485-7. doi: 10.1007/BF00607965.

DOI:10.1007/BF00607965
PMID:3017723
Abstract

Increased sympathetic activity occurs in congestive heart failure and may have deleterious effects. To examine the effects of angiotensin converting enzyme (ACE) inhibition on sympathetic activity in heart failure, the noradrenaline response to exercise was measured in 18 patients given enalapril or placebo in double-blind trial. The plasma noradrenaline response to graded exercise was significantly reduced after 4 weeks on active treatment but was unchanged by placebo treatment. The rate-pressure product at maximal exercise was significantly reduced after 4 weeks in the enalapril group but unchanged in the placebo group. These results suggest that ACE inhibition reduces sympathetic activity in patients with heart failure.

摘要

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本文引用的文献

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Role of vasopressin in hypertension: studies using the Brattleboro rat.血管加压素在高血压中的作用：使用布氏大鼠的研究
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Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure.血浆去甲肾上腺素作为慢性充血性心力衰竭患者预后的一项指标。
N Engl J Med. 1984 Sep 27;311(13):819-23. doi: 10.1056/NEJM198409273111303.
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Enalapril in patients with chronic heart failure: a placebo-controlled, randomized, double-blind study.依那普利治疗慢性心力衰竭患者：一项安慰剂对照、随机、双盲研究。
Circulation. 1984 Aug;70(2):271-8. doi: 10.1161/01.cir.70.2.271.
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Central and peripheral indices of sympathetic activity after blood pressure lowering with enalapril (MK-421) or hydralazine in normotensive rats.依那普利（MK - 421）或肼苯哒嗪降低正常血压大鼠血压后交感神经活动的中枢和外周指标
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Captopril interferes with neurogenic vasoconstriction in the pithed rat by angiotensin-dependent mechanisms.卡托普利通过血管紧张素依赖性机制干扰脊髓麻醉大鼠的神经源性血管收缩。
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