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Effect of 3-[2-[4-(o-methoxyphenyl)-1-piperazinyl]ethyl]-2,4(1H,3H)- quinazolinedione monophydrochloride (SGB-1534), an antihypertensive agent, on 3H-prazosin and 3H-p-aminoclonidine binding to alpha 1- and alpha 2-adrenoceptors in dog brain and aorta.

作者信息

Nagatomo T, Aono J, Tajiri A, Nakamura T, Tsuchihashi H

出版信息

Chem Pharm Bull (Tokyo). 1988 Mar;36(3):1122-7. doi: 10.1248/cpb.36.1122.

DOI:10.1248/cpb.36.1122
PMID:2900699
Abstract
摘要

相似文献

1
Effect of 3-[2-[4-(o-methoxyphenyl)-1-piperazinyl]ethyl]-2,4(1H,3H)- quinazolinedione monophydrochloride (SGB-1534), an antihypertensive agent, on 3H-prazosin and 3H-p-aminoclonidine binding to alpha 1- and alpha 2-adrenoceptors in dog brain and aorta.抗高血压药3-[2-[4-(邻甲氧基苯基)-1-哌嗪基]乙基]-2,4(1H,3H)-喹唑啉二酮单盐酸盐（SGB-1534）对3H-哌唑嗪和3H-对氨基可乐定与犬脑和主动脉中α1和α2肾上腺素能受体结合的影响。
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2
Alpha-blocking potencies of antihypertensive agents (prazosin, terazosin, bunazosin, SGB-1534 and ketanserin) having with quinazoline or quinazolinedione as assessed by radioligand binding assay methods in rat brain.
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3
Displacement by alpha-adrenergic agonists and antagonists of 3H-prazosin bound to the alpha-adrenoceptors of the dog aorta and the rat brain.α-肾上腺素能激动剂和拮抗剂对与犬主动脉及大鼠脑α-肾上腺素能受体结合的3H-哌唑嗪的置换作用。
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4
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5
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Chloroethylclonidine discriminates between alpha 1A- and alpha 1B-adrenoceptors in the presence of guanosine 5'-triphosphate in rabbit thoracic aorta.在兔胸主动脉中，氯乙可乐定在存在鸟苷 5'-三磷酸的情况下可区分α1A-和α1B-肾上腺素能受体。
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Characterization of a novel alpha 1-adrenoceptor antagonist, SGB-1534, in contractile response of isolated canine arterial and venous smooth muscle to exogenous noradrenaline: comparison with prazosin, phentolamine and yohimbine.新型α1肾上腺素能受体拮抗剂SGB - 1534对离体犬动脉和静脉平滑肌对外源性去甲肾上腺素收缩反应的特性研究：与哌唑嗪、酚妥拉明和育亨宾的比较
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8
Potent alpha-adrenoceptor blocking action of SGB-1534, a new quinazoline antihypertensive agent in vitro experiments.新型喹唑啉类抗高血压药物SGB - 1534在体外实验中具有强效α - 肾上腺素能受体阻断作用。
Gen Pharmacol. 1986;17(2):143-9. doi: 10.1016/0306-3623(86)90131-x.
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The relationship between density of alpha-adrenoceptor binding sites and contractile responses in several porcine isolated blood vessels.几种猪离体血管中α-肾上腺素能受体结合位点密度与收缩反应之间的关系。
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