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[氯菲宁对血小板聚集的作用]

[Effect of clopheline on thrombocyte aggregation].

作者信息

Ivleva A Ia, Baluda M V, Kobalava Zh D, Novikova I V, Beloshitskaia N I

出版信息

Kardiologiia. 1988 May;28(5):80-3.

PMID:2900910
Abstract

Data on clopheline effect on platelet aggregation, both spontaneous and ADP- or adrenaline-induced, in normal donors are reported. Clopheline is shown to slightly increase aggregation in normal subjects, exhibiting properties of a weak aggregation inductor. Where adrenaline is present in the aggregating system, clopheline undermines its platelet aggregation-inducing effect and, consequently, shows properties of a more competitive antagonist, as compared to adrenaline.

摘要

报告了氯苯乙胺对正常献血者血小板聚集(包括自发性聚集以及由二磷酸腺苷或肾上腺素诱导的聚集)的影响数据。结果显示,氯苯乙胺可使正常受试者的血小板聚集略有增加,表现出弱聚集诱导剂的特性。在聚集系统中存在肾上腺素的情况下,氯苯乙胺会削弱其血小板聚集诱导作用,因此,与肾上腺素相比,它表现出更具竞争性拮抗剂的特性。

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