一种不抑制单核细胞吞噬作用的细胞生长抑制剂（紫杉醇）。
A cytostatic drug (taxol) which does not inhibit monocyte phagocytosis.
作者信息
Athlin L, Domellöf L, Norberg B
机构信息
Department of Surgery, University Hospital, Umeå, Sweden.
出版信息
Med Oncol Tumor Pharmacother. 1988;5(2):135-8. doi: 10.1007/BF02985453.
PMID:2900916
Abstract
Taxol is a new cytotoxic agent which arrests cell division in the G2 and the M phases, due to its unique property of inhibiting microtubule function by stabilization. In contrast to other microtubule antagonists except griseofulvin, taxol did not inhibit monocyte phagocytosis. It is suggested that lack of interference with the function of mature leukocytes may reduce the immunosuppression induced by a cytotoxic agent.
摘要
紫杉醇是一种新型细胞毒性药物，它能使细胞分裂停滞在G2期和M期，这归因于其通过稳定作用抑制微管功能的独特特性。与除灰黄霉素之外的其他微管拮抗剂不同，紫杉醇并不抑制单核细胞的吞噬作用。有人认为，不干扰成熟白细胞的功能可能会减轻细胞毒性药物所致的免疫抑制。
Zotero 插件