非甾体抗炎芬那酸盐类药物对前列腺素E受体结合的影响。
Effect of fenamates on prostaglandin E receptor binding.
作者信息
Rees M C, Cañete-Solér R, López Bernal A, Turnbull A C
机构信息
Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford.
出版信息
Lancet. 1988 Sep 3;2(8610):541-2. doi: 10.1016/s0140-6736(88)92660-8.
PMID:2900923
Abstract
The effect of fenamates on prostaglandin E receptor binding was examined in myometrial samples collected at hysterectomy. Sodium meclofenamate and mefenamic acid inhibited binding of PGE2 to its specific receptor in a dose-dependent manner, with an ED50 of 20 mumol/l and 200 mumol/l, respectively.
摘要
在子宫切除术中收集的子宫肌层样本中检测了芬那酸盐对前列腺素E受体结合的影响。甲氯芬那酸钠和甲芬那酸以剂量依赖性方式抑制PGE2与其特异性受体的结合，ED50分别为20 μmol/l和200 μmol/l。
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