脑内多巴胺能移植体不会被激活原位中脑皮质边缘神经元的电休克应激所激活。

Intracerebral dopaminergic transplants are not activated by electrical footshock stress activating in situ mesocorticolimbic neurons.

作者信息

Herman J P, Rivet J M, Abrous N, Le Moal M

机构信息

INSERM U259, Université de Bordeaux II, Bordeaux, France.

出版信息

Neurosci Lett. 1988 Jul 19;90(1-2):83-8. doi: 10.1016/0304-3940(88)90791-4.

DOI:10.1016/0304-3940(88)90791-4

PMID:2901059

Abstract

Male rats received a dopaminergic implant aimed either at the nucleus accumbens or the ventral tegmental area (VTA) following 6-hydroxydopamine lesion of their mesocorticolimbic dopaminergic system. Exposure to electrical footshock stress 6 months later markedly activated the mesocorticolimbic neurons in control animals as shown by the increase of dihydroxyphenylacetic acid (DOPAC) levels both in the nucleus accumbens and the VTA. However, no stress-induced activation was seen for the grafted neurons, irrespective of the area of implantation. These results indicate the lack of reinnervation and modulation of the grafted dopaminergic neurons by one of the important afferent systems regulating the activity of endogenous mesencephalic dopaminergic neurons.

摘要

在雄性大鼠的中脑皮质边缘多巴胺能系统经6-羟基多巴胺损伤后，对其伏隔核或腹侧被盖区（VTA）植入多巴胺能移植物。6个月后，对大鼠施加电休克应激，结果显示，对照组动物的中脑皮质边缘神经元被显著激活，这表现为伏隔核和VTA中3,4-二羟基苯乙酸（DOPAC）水平升高。然而，无论植入区域如何，移植神经元均未出现应激诱导的激活。这些结果表明，调节内源性中脑多巴胺能神经元活动的重要传入系统之一，缺乏对移植多巴胺能神经元的再支配和调节作用。