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印防己毒素和尼克酸对腹侧被盖区多巴胺能神经元对伏隔核刺激的抑制反应的影响。

Effect of picrotoxin and nipecotic acid on inhibitory response of dopaminergic neurons in the ventral tegmental area to stimulation of the nucleus accumbens.

作者信息

Yim C Y, Mogenson G J

出版信息

Brain Res. 1980 Oct 20;199(2):466-73. doi: 10.1016/0006-8993(80)90705-2.

DOI:10.1016/0006-8993(80)90705-2
PMID:7417797
Abstract

Electrical stimulation of nucleus accumbens inhibited the activity of neurons in the ventral tegmental area (VTA). Inhibition was potentiated by nipecotic acid, a GABA uptake inhibitor, and was attenuated by picrotoxin, a GABA antagonist. Four units inhibited by nucleus accumbens stimulation were also antidromically activated. These observations suggest that neurons in the VTA, including specifically those projecting to the nucleus accumbens, receive a descending GABAergic input from that area.

摘要

伏隔核的电刺激抑制了腹侧被盖区（VTA）神经元的活动。抑制作用被GABA摄取抑制剂尼克酸增强，被GABA拮抗剂印防己毒素减弱。4个被伏隔核刺激抑制的单位也被逆向激活。这些观察结果表明，VTA中的神经元，特别是那些投射到伏隔核的神经元，接受来自该区域的下行GABA能输入。

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