Spieker C, Vetter H, Liedtke R, Zidek W, Vetter W
Medizinische Universitäts-Poliklinik, Münster, Federal Republic of Germany.
Am J Hypertens. 1988 Jul;1(3 Pt 3):199S-200S. doi: 10.1093/ajh/1.3.199s.
Transdermal drug delivery has been applied to various agents in an effort to decrease the frequency of drug administration and increase the patients compliance. In our study, we demonstrated that transdermal application of a beta-blocker (20 mg mepindolol) in patients with essential hypertension led to effective blood pressure lowering effect within 1 week (160.1 +/- 6.1 mm Hg/95.8 +/- 8.3 mm Hg vs 136.8 +/- 7.2 mm Hg/84.3 +/- 5.0 mm Hg; P less than 0.05). A controlled study of transdermal versus oral beta-blocker administration in hypertensives is necessary before this new therapeutic system is introduced in antihypertensive treatment.
经皮给药已应用于多种药物，旨在减少给药频率并提高患者的依从性。在我们的研究中，我们证明，对原发性高血压患者经皮应用一种β受体阻滞剂（20mg美吲哚洛尔）在1周内产生了有效的降压效果（160.1±6.1mmHg/95.8±8.3mmHg对136.8±7.2mmHg/84.3±5.0mmHg；P<0.05）。在将这种新的治疗系统引入抗高血压治疗之前，有必要对高血压患者进行经皮与口服β受体阻滞剂给药的对照研究。
