Kaskel F J, Devarajan P, Persan L, Juno C J, Wilson T A, McCaughran J A
Department of Pediatrics, School of Medicine, State University of New York, Stony Brook 11794.
Am J Hypertens. 1988 Jul;1(3 Pt 3):41S-44S. doi: 10.1093/ajh/1.3.41s.
The inbred S/JR rat is characterized by a genetic predisposition to NaCl-induced hypertension. Although mature S/JR but not R/JR rats develop hypertension when fed a high NaCl-containing diet, this effect has not been examined during early neonatal development. S/JR and R/JR dams were maintained on 0.15% (w/w) or 8% (w/w) NaCl diets throughout gestation and lactation. Measurements of mean abdominal aortic blood pressure (MAP) were obtained in anesthetized offspring at 5, 15, and 25 days of age. This was greater in neonatal S/JR rats than R/JR rats at 5, 15, and 25 days of age. A hypertensinogenic effect of 8% NaCl was seen in R/JR at 5 and 15 days. The results indicate that the ontogeny of MAP can be influenced by pre- and postnatal dietary NaCl. More importantly, elevated MAP in the S/JR strain is a distinguishing characteristic evident throughout the neonatal period of development.
近交系S/JR大鼠的特点是具有对氯化钠诱导的高血压的遗传易感性。虽然成熟的S/JR大鼠而非R/JR大鼠在喂食高氯化钠饮食时会发生高血压，但在新生儿早期发育过程中尚未对此效应进行研究。在整个妊娠期和哺乳期，将S/JR和R/JR母鼠维持在0.15%（w/w）或8%（w/w）的氯化钠饮食中。在5、15和25日龄的麻醉后代中测量平均腹主动脉血压（MAP）。在5、15和25日龄时，新生S/JR大鼠的MAP高于R/JR大鼠。在5和15日龄时，8%氯化钠对R/JR大鼠有高血压生成作用。结果表明，产前和产后饮食中的氯化钠可影响MAP的个体发生。更重要的是，S/JR品系中升高的MAP是在整个新生儿发育阶段都明显的一个显著特征。
