Wilson T A, McCaughran J A, Juno C J, Kaskel F J, Partin J S
J Hypertens Suppl. 1986 Dec;4(5):S23-6.
Plasma renin activity (PRA) is characteristically lower in the Dahl salt-sensitive (S) rat than in the salt-resistant (R) rat. To establish whether PRA differs between these strains at birth or subsequently becomes suppressed in the Dahl S rat, the ontogeny of PRA was studied in inbred Dahl hypertension-prone (S/JR) and hypertension-resistant (R/JR) rats from 5 to 51 days of age. Pregnant dams and postweaning pups were maintained on diets containing either 0.15% or 0.69% sodium chloride (w:w). Although PRA clearly distinguished the two strains in young adulthood, it was not lower in the S/JR pups at 5 and 15 days of age. However, PRA was greater in rat pups suckling dams consuming the low salt diet. These results suggest that suppressed PRA in S/JR rats is an acquired trait, perhaps occurring secondary to other physiological abnormalities and that maternal diet influences PRA in the suckling Dahl rat.
血浆肾素活性（PRA）在 Dahl 盐敏感（S）大鼠中通常低于盐抵抗（R）大鼠。为了确定这些品系在出生时 PRA 是否存在差异，或者 Dahl S 大鼠随后 PRA 是否受到抑制，对 5 至 51 日龄的近交 Dahl 高血压易感（S/JR）和高血压抵抗（R/JR）大鼠的 PRA 个体发生情况进行了研究。怀孕母鼠和断奶后的幼鼠分别维持在含 0.15%或 0.69%氯化钠（w:w）的饮食中。尽管 PRA 在成年早期能明显区分这两个品系，但在 5 日龄和 15 日龄的 S/JR 幼鼠中，PRA 并不低。然而，吸食食用低盐饮食母鼠乳汁的幼鼠 PRA 更高。这些结果表明，S/JR 大鼠中 PRA 受到抑制是一种后天获得的特征，可能继发于其他生理异常，并且母体饮食会影响哺乳 Dahl 大鼠的 PRA。
