Linthicum D S, Bolger M B, Kussie P H, Albright G M, Linton T A, Combs S, Marchetti D
Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, Houston 77225.
Clin Chem. 1988 Sep;34(9):1676-80.
Antibodies to small bioactive ligands and peptides may mimic the binding characteristics of the natural receptor; in turn, the anti-idiotypic antibodies generated against the binding sites of such anti-ligand antibodies may mimic some aspects of small bioactive ligands and peptides. Among the several levels of investigation of such antibody-receptor networks are (a) the quantitative structure-activity relationships of ligand binding to antibody as compared with natural receptor; (b) the molecular modeling of antibody-receptor binding sites and the genomic basis for such structures; and (c) the characteristics of the molecular mimicry exhibited by "mimetopes" on anti-idiotypic antibodies. To illustrate the analysis encountered at each of these levels, we discuss here antibody and anti-idiotypic systems that are directed to small neuroactive ligands and their receptors.
针对小生物活性配体和肽的抗体可能模拟天然受体的结合特性；反过来，针对此类抗配体抗体结合位点产生的抗独特型抗体可能模拟小生物活性配体和肽的某些方面。在对此类抗体 - 受体网络的几个研究层面中，包括：（a）与天然受体相比，配体与抗体结合的定量构效关系；（b）抗体 - 受体结合位点的分子建模以及此类结构的基因组基础；（c）抗独特型抗体上“模拟表位”所表现出的分子模拟特征。为了说明在这些层面中的每一个层面所遇到的分析情况，我们在此讨论针对小神经活性配体及其受体的抗体和抗独特型系统。
