钒酸盐增强辣椒素诱导的豚鼠气管平滑肌收缩

Enhancement of capsaicin-induced contraction of guinea-pig tracheal smooth muscle by vanadate.

作者信息

Nayler R A

机构信息

Department of Physiology, University of Western Australia, Nedlands.

出版信息

J Pharm Pharmacol. 1988 Jun;40(6):443-5. doi: 10.1111/j.2042-7158.1988.tb06314.x.

DOI:10.1111/j.2042-7158.1988.tb06314.x

PMID:2901479

Abstract

Contractions of guinea-pig isolated tracheal smooth muscle by submaximal capsaicin (0.1 microM) were enhanced by 43% (P less than 0.01) after vanadate (10 microM for 10 min) preincubation. Contractile responses to acetylcholine (0.1-100 microM), histamine (1-100 microM) or substance P (0.01-1 microM) were, in contrast, not affected by prior vanadate exposure. It is suggested that tachykinin release from capsaicin-sensitive afferent nerve endings within the airways was enhanced by vanadate while airway smooth muscle reactivity remained unchanged.

摘要

用钒酸盐（10微摩尔/升，作用10分钟）预孵育后，豚鼠离体气管平滑肌对亚最大浓度辣椒素（0.1微摩尔/升）的收缩反应增强了43%（P<0.01）。相比之下，对乙酰胆碱（0.1 - 100微摩尔/升）、组胺（1 - 100微摩尔/升）或P物质（0.01 - 1微摩尔/升）的收缩反应不受预先钒酸盐暴露的影响。这表明，钒酸盐增强了气道内对辣椒素敏感的传入神经末梢的速激肽释放，而气道平滑肌反应性保持不变。