用A型肉毒毒素治疗顽固性便秘中的盆底痉挛综合征。
Treatment of anismus in intractable constipation with botulinum A toxin.
作者信息
Hallan R I, Williams N S, Melling J, Waldron D J, Womack N R, Morrison J F
机构信息
Surgical Unit, London Hospital, Whitechapel.
出版信息
Lancet. 1988 Sep 24;2(8613):714-7. doi: 10.1016/s0140-6736(88)90188-2.
In seven patients with anismus the striated sphincter muscle complex was selectively weakened by local injection of Clostridium botulinum type A toxin. Symptom scores improved significantly and correlated with a significant reduction in the maximum voluntary and canal squeeze pressure and a significant increase in the anorectal angle on straining. Botulinum A toxin seems to be promising treatment for some patients with anismus.
在7例盆底失弛缓综合征患者中，通过局部注射A型肉毒杆菌毒素选择性地减弱了横纹括约肌复合体的功能。症状评分显著改善，且与最大自主收缩压力和肛管收缩压力的显著降低以及用力排便时肛管直肠角的显著增大相关。A型肉毒杆菌毒素似乎是治疗某些盆底失弛缓综合征患者的一种有前景的方法。
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