阿尔茨海默病老年斑中的淀粉样前体蛋白。 - Suppr

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超能文献

Amyloid precursor protein in senile plaques of Alzheimer disease.

作者信息

Perry G, Lipphardt S, Mulvihill P, Kancherla M, Mijares M, Gambetti P, Sharma S, Maggiora L, Cornette J, Lobl T

出版信息

Lancet. 1988 Sep 24;2(8613):746. doi: 10.1016/s0140-6736(88)90219-x.

DOI:10.1016/s0140-6736(88)90219-x

PMID:2901596

Abstract

摘要

相似文献

Amyloid precursor protein in senile plaques of Alzheimer disease.阿尔茨海默病老年斑中的淀粉样前体蛋白。

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Identification of cellular and extracellular sites of amyloid precursor protein extracytoplasmic domain in normal and Alzheimer disease brains.正常和阿尔茨海默病大脑中淀粉样前体蛋白胞外结构域的细胞内和细胞外位点的鉴定。

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Immunolocalization of the amyloid precursor protein within the senile plaque.老年斑内淀粉样前体蛋白的免疫定位

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Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein.阿尔茨海默病中的老年斑神经突会积累淀粉样前体蛋白。

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[Biochemical and molecular study of amyloid protein A4 deposited in senile plaques].[沉积于老年斑中的淀粉样蛋白A4的生化与分子研究]

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Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques.特定的神经丝、tau蛋白和β-淀粉样前体蛋白表位可区分阿尔茨海默病与非阿尔茨海默病的老年斑。

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Molecular pathology of the amyloid A4 precursor of Alzheimer's disease.

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Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease.阿尔茨海默病中，突触前蛋白NACP的改变与斑块形成和神经退行性变相关。

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Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.阿尔茨海默病的β-淀粉样前体蛋白以110至135千道尔顿的膜相关蛋白形式存在于神经组织和非神经组织中。

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Inhibition of amyloid precursor protein processing enhances gemcitabine-mediated cytotoxicity in pancreatic cancer cells.抑制淀粉样前体蛋白的处理可增强吉西他滨对胰腺癌细胞的细胞毒性。

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Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation.阿尔茨海默病和衰老过程中微管减少与tau细丝形成无关。

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Synaptic pathology and glial responses to neuronal injury precede the formation of senile plaques and amyloid deposits in the aging cerebral cortex.在衰老的大脑皮质中，突触病理学以及胶质细胞对神经元损伤的反应先于老年斑和淀粉样沉积物的形成。

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