Schmidt H L
a Lehrstuhl für Biologische Chemie der Technischen Universität München Freising-Weihenstephan , Germany.
Isotopes Environ Health Stud. 1999 Sep;35(1-2):11-18. doi: 10.1080/10256019908234076.
The global isotope abundance of natural organic compounds is determined by that of their precursors. A prerequisite for the formation of non-statistical intermolecular and intramolecular isotope distributions is the occurance of thermodynamic and kinetic isotope effects in irreversible and branched metabolic processes. This coincidence permits the interference of external factors like climatological conditions during biosynthesis, thus leading to corresponding modulations of isotope fractionations. The general principles of the in-vivo isotope discrimination are outlined and the individual properties of the different bioelements in this system are described. The results are discussed in regard to obtain maximum information about the origin and authenticity of a natural compound by multielement isotope analysis.
天然有机化合物的全球同位素丰度由其前体的同位素丰度决定。形成非统计性分子间和分子内同位素分布的一个先决条件是在不可逆和分支代谢过程中发生热力学和动力学同位素效应。这种巧合使得生物合成过程中诸如气候条件等外部因素能够产生干扰，从而导致同位素分馏的相应调制。概述了体内同位素歧视的一般原则，并描述了该系统中不同生物元素的个体特性。讨论了通过多元素同位素分析获取有关天然化合物的来源和真实性的最大信息的结果。
