Jung Lae Young, Jeon Mir, Choi Seung Hee, Hwang Joo-Hee, Lee Chang-Seop, Rhee Kyoung-Suk
Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Republic of Korea.
Department of Internal Medicine, Chonbuk National University, Jeonju, Republic of Korea.
Am J Trop Med Hyg. 2017 Nov;97(5):1316-1318. doi: 10.4269/ajtmh.17-0259. Epub 2017 Oct 10.
To investigate the relationship between heart rate and temperature, we examined 493 febrile patients with documented disease. These patients were diagnosed serologically and analyzed retrospectively: 337 (68.4%) responded to fever with increased heart rate < 10 beats/minute/°C (relative bradycardia [RB]), and 156 patients had a heart rate response ≥ 10 beats/minute/°C (general heart rate increase [GHRI]). The RB group had a higher median resting heart rate and lower heart rate at maximum temperature than the GHRI group. Despite differences in heart rate response, no significant differences were seen in clinical outcomes (acute kidney injury, systemic inflammatory response syndrome (SIRS), and death). We concluded that most patients with scrub typhus presented with RB. In scrub typhus infection, RB can be included as one of the clinical features for differential diagnosis from other infectious diseases.
为研究心率与体温之间的关系，我们检查了493例有明确疾病记录的发热患者。这些患者经血清学诊断并进行回顾性分析：337例（68.4%）对发热的心率反应为每分钟增加心率<10次/°C（相对心动过缓[RB]），156例患者的心率反应≥每分钟10次/°C（一般心率增加[GHRI]）。RB组的静息心率中位数较高，最高体温时的心率低于GHRI组。尽管心率反应存在差异，但临床结局（急性肾损伤、全身炎症反应综合征[SIRS]和死亡）未见显著差异。我们得出结论，大多数恙虫病患者表现为RB。在恙虫病感染中，RB可作为与其他传染病进行鉴别诊断的临床特征之一。
