两名来自东非的寻求庇护者虽显微镜检查结果为阴性，但仍被诊断为虱传回归热
Diagnosis of Louse-Borne Relapsing Fever despite Negative Microscopy in Two Asylum Seekers from Eastern Africa.
作者信息
Antinori Spinello, Tonello Cristina, Edouard Sophie, Parravicini Carlo, Gastaldi Daniela, Grande Romualdo, Milazzo Laura, Ricaboni Davide, Fenollar Florence, Raoult Didier, Corbellino Mario, Mediannikov Oleg
机构信息
III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Milano, Italy.
Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milano, Milano, Italy.
出版信息
Am J Trop Med Hyg. 2017 Dec;97(6):1669-1672. doi: 10.4269/ajtmh.17-0320. Epub 2017 Sep 21.
Abstract
We report two cases of louse-borne relapsing fever observed at our Institution in June 2016. Both patients were young asylum seekers from Africa who had recently arrived in Milan, Italy. Notably, direct microscopic examination of peripheral blood smears was repeatedly negative for the presence of spirochetes and the diagnosis, supported by clinical and epidemiologic evidence, required molecular confirmation by polymerase chain reaction amplification of DNA extracted from blood and sequencing of the amplified products.
摘要
我们报告了2016年6月在我们机构观察到的两例虱传回归热病例。两名患者均为来自非洲的年轻寻求庇护者，他们最近抵达了意大利米兰。值得注意的是，外周血涂片的直接显微镜检查多次未发现螺旋体，在临床和流行病学证据的支持下，诊断需要通过聚合酶链反应扩增血液中提取的DNA并对扩增产物进行测序来进行分子确认。
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