Young Alice, Tacon Catherine, Smith Simon, Reeves Ben, Wiseman Greg, Hanson Josh
Department of Intensive Care, Cairns Hospital, Cairns, Australia.
James Cook University, Cairns, Australia.
Am J Trop Med Hyg. 2017 Dec;97(6):1691-1694. doi: 10.4269/ajtmh.17-0650. Epub 2017 Sep 28.
With prompt administration of appropriate antimicrobial therapy and access to modern intensive care support, fatal pediatric melioidosis is very unusual. We describe cases of two children in whom the possibility of melioidosis was recognized relatively early, but who died of the disease, despite receiving optimal supportive care. We discuss the resulting implications for bacterial virulence factors in disease pathogenesis.
通过及时给予适当的抗菌治疗并获得现代重症监护支持，儿童类鼻疽病致死情况非常罕见。我们描述了两名儿童的病例，他们的类鼻疽病可能性相对较早被识别，但尽管接受了最佳支持治疗，仍死于该病。我们讨论了由此对疾病发病机制中细菌毒力因子的影响。
