Pyziak Aleksandra, Zmyslowska Agnieszka, Bobeff Katarzyna, Malachowska Beata, Fendler Wojciech, Wyka Krystyna, Baranowska-Jazwiecka Anna, Szymanska Malgorzata, Szadkowska Agnieszka, Mlynarski Wojciech
.
J Pediatr Endocrinol Metab. 2017 Oct 26;30(11):1147-1153. doi: 10.1515/jpem-2017-0100.
The aim of the study was to compare the selected markers in children with and without partial clinical remission (CR) of newly diagnosed type 1 diabetes (T1D).
The study group consisted of 186 patients (F/M; 87/99) at onset of T1D and 24 months of follow-up. Partial CR was defined as insulin requirement <0.5 IU/kg and glycated hemoglobin (HbA1c) <7%.
Partial CR was observed in 115/186 (61.83%) of patients. At diagnosis body mass index standard deviation (BMI SDS) was higher among remitters than in non-remitters (p=0.0051) and remitters were younger (p=0.0029). In the follow-up a higher triglyceride concentration in non-remitters compared to remitters (p=0.0455) and a lower high density lipoprotein (HDL) cholesterol level (p=0.0119) were noticed.
Younger age and higher BMI at diagnosis of T1D can predispose to partial CR in children. In patients with CR of T1D after 2 years of follow-up a lipid profile improvement is observed.
本研究旨在比较新诊断的1型糖尿病（T1D）患儿中达到部分临床缓解（CR）与未达到部分临床缓解的患儿的选定标志物。
研究组由186例T1D发病时及随访24个月的患者组成（男/女；87/99）。部分CR定义为胰岛素需求量<0.5 IU/kg且糖化血红蛋白（HbA1c）<7%。
115/186（61.83%）的患者出现部分CR。诊断时，缓解者的体重指数标准差（BMI SDS）高于未缓解者（p=0.0051），且缓解者更年轻（p=0.0029）。随访期间，未缓解者的甘油三酯浓度高于缓解者（p=0.0455），高密度脂蛋白（HDL）胆固醇水平低于缓解者（p=0.0119）。
T1D诊断时年龄较小和BMI较高可能使儿童易发生部分CR。T1D患者随访2年后达到CR时，血脂状况有所改善。
